NeuroImage publication

Abstract
Multi-modal brain imaging was used to examine the relation between individual differences in resting-state striatal dopamine D2 binding and the magnitude of prefrontal BOLD activation during updating of long-term memory (LTM) representations. Increased activity in left prefrontal cortex was observed when LTM updating was required, and there was a positive correlation between striatal D2 activity and the magnitude of left prefrontal activity during updating. These findings support predictions from neurocomputational models of a relation of dopaminergic neurotransmission to transient cognitive operations and related brain activity.

Nyberg, L., et al., Striatal dopamine D2 binding is related to frontal BOLD response during updating of long-term
memory representations, NeuroImage (2009), doi:10.1016/j.neuroimage.2009.03.035